Understanding the Uses and Effects of Abrocitinib

Table of Contents

Introduction to Abrocitinib
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Abrocitinib is an effective medication specifically designed for managing moderate to severe atopic dermatitis that doesn’t sufficiently respond to traditional treatments. Available in tablet form, it should only be used under the guidance of a doctor.

Understanding Abrocitinib
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Abrocitinib belongs to a class of drugs known as Janus kinase (JAK) inhibitors. These are compounds that play a crucial role in the inflammation process associated with eczema or atopic dermatitis. This medication is suitable for adults and children aged 12 years and older.

Brand Name: Freorla
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What Is Abrocitinib?
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Classification
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Prescription Drug

Category
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Immunosuppressive Agents

Benefits
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Treats Atopic Dermatitis

Suitable For
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Adults and Children Aged ≥12 years

Use During Pregnancy and Breastfeeding
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Pregnancy Category Z: There are no controlled studies in pregnant women. Animal studies show potential congenital defects.
The absorption of Abrocitinib into breast milk is not well understood. Therefore, consult a doctor before use if breastfeeding.

Formulation
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Tablet

Precautions Before Taking Abrocitinib
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Before starting Abrocitinib, several considerations need attention:

Allergy Information: Inform the doctor about any known allergies. This medication should not be taken by individuals allergic to it.
Drug Interactions: Notify the doctor if taking antiplatelet medications. Abrocitinib should not be combined with these, except for low-dose aspirin.
Existing Conditions: Discuss any severe liver conditions or infections, including TB, as Abrocitinib is not recommended for these patients.
Medical History: Mention any history of heart disease, kidney issues, liver disease, blood clotting disorders, immune system problems, anemia, or cancer.
Ongoing Treatments: Disclose current treatments with immunosuppressants and avoid close contact with contagious diseases, as Abrocitinib increases infection risk.
Vaccinations: Do not receive live vaccines during Abrocitinib treatment.
Pregnancy and Plans: Consult a doctor if pregnant, breastfeeding, or planning a pregnancy.
Medication Disclosure: Inform the doctor about other medications, supplements, or herbal products in use to prevent unwanted drug interactions.

Recommended Dosage and Administration
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Dosage is tailored by the doctor based on age and the patient’s condition. Typically, the dosage for treating atopic dermatitis is:

Adults and Children Aged ≥12 years: 100 mg daily. If there is an inadequate response after 12 weeks, the dose can increase to 200 mg daily.

Proper Administration of Abrocitinib
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Follow the doctor’s advice and read the packaging instructions before taking Abrocitinib. Do not alter the dose without approval.

Administration: Abrocitinib can be taken with or without food. Swallow the tablet with water.
Consistency: Take the medication regularly at the same time each day to maximize effectiveness.
Missed Dose: If you miss a dose, take it once remembered. However, if it is close to the next scheduled dose, skip the missed dose.
Sun Sensitivity: Abrocitinib may increase sunburn risk. Use sunscreen and wear protective clothing outdoors.
Infection Precaution: Avoid direct contact with infectious diseases due to decreased immunity.
Storage: Store at room temperature, away from moisture and sunlight, and out of children’s reach.

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Potential Drug Interactions
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Abrocitinib may interact with other medications, such as:

Increased Bleeding Risk: If used with antiplatelet drugs like anagrelide.
Infection Risk: Heightened with immunosuppressants like adalimumab or cilostazol.
Vaccine Interactions: Reduced effectiveness with live vaccines like BCG.
Enhanced Effectiveness: Noted with fluconazole or fluvoxamine.
Reduced Effectiveness: When taken with rifampicin.

Always consult a healthcare provider before combining Abrocitinib with other medications to mitigate interaction risks.